Metabolomic Biomarkers of Toxicity
Metabolomics is the exhaustive characterization of metabolite concentrations in biofluids and tissues. The use of NMR and chromatography-linked mass spectrometry to assay metabolic profiles of tissue homogenates and biofluids has been increasingly recognized as a powerful tool for biological discovery. In recent years metabolomics techniques have been applied to a wide variety of diagnostic, preclinical, systems biology, and ecological studies. Working with Dr. Nicholas Reo’s Nuclear Magnetic Resonance Lab at Wright State University, we are developing standards-based tools and web services for the pre-processing, normalization/standardization, exploratory and comparative analysis, and visualization of NMR spectra from biofluids.Metabolomics is the exhaustive characterization of metabolite concentrations in biofluids and tissues. The use of NMR and chromatography-linked mass spectrometry to assay metabolic profiles of tissue homogenates and biofluids has been increasingly recognized as a powerful tool for biological discovery. In recent years metabolomics techniques have been applied to a wide variety of diagnostic, preclinical, systems biology, and ecological studies. Working with Dr. Nick Reo’s NMR spectroscopy lab at Wright State University, we are developing standards-based tools and web services for the pre-processing, normalization/standardization, exploratory and comparative analysis, and visualization of NMR spectra from biofluids, the newest of which is Omics Dashboard.