Dr. Raymer's laboratory employs computational techniques and novel
algorithms to investigate problems in biochemistry and
molecular biology. From the encoding of heritable information in DNA
to the structure and function of proteins, we are currently pursuing
investigations that span a broad range of biological questions. Key
studies currently underway include:
* Pattern analysis in high-dimensionality data sets.
* Nuclear Magnetic Resonance based Metabolomics. Identifying biomarkers of
toxicity and disease from NMR assays of metabolite concentration in
biofluids and tissues.
* Development and validation of computational and experimental methods for
the analysis and interpretation of forensic DNA.
* Development of a hybrid experimental/computational technique for
high-confidence prediction of protein tertiary and quaternary
structure;
* Investigation of preferences in amino acid usage among prokaryotic
organisms in relation to their energy usage strategy;
* Application of computational pattern recognition to elucidate the
role of water molecules in protein-ligand binding;
* Analysis of substitutional bias in higher organisms, including
an investigation of the role of male germ line cells as the
driving force in mammalian evoltion.
* Devlopment of rapid indexing methods to provide higher confidence
searches for biological (DNA and protein) sequences. employs computational techniques and novel
We develop algorithms to investigate problems in biochemistry and molecular biology. From the encoding of heritable information in DNA to the structure and function of proteins, we are currently pursuing investigations that span a broad range of biological questions. Our research interests include pattern analysis in high-dimensionality data sets, evolutionary computation and optimization, and multivariate statistics. We apply our research to a variety of problems from biochemistry and molecular biology. We currently have projects underway in metabolomics, molecular evolution, protein structure, and remote homolog search. Take a look at the projects page for more information.
